JOT has developed a unique platform product, JOTROL™, which is a patented reformulation of the well known "wonder" medication resveratrol. Resveratrol is poorly soluble and is rapidly metabolized by the liver which requires high doses for therapeutic effect, but is then associated with severe GI side effects. JOTROL™ significantly increases absorption and thereby is expected to generate therapeutic effect at a low dose of ingested resveratrol and without GI side effects. JOTROL™ is potentially a safe and effective product for treatment in several diseases. One of the key mechanisms of action, besides modulating gene expression and activation of Sirtuins, is a boost of mitochondrial biogenesis as described below.