​JOT has developed a unique platform product, JOTROL™​, a patented reformulation of the well known "wonder" medication resveratrol. Resveratrol is poorly soluble and is rapidly metabolized by the liver which requires high doses for therapeutic effect, but is then associated with severe GI side effects. JOTROL™​ delivers resveratrol in a highly bioavailbe form which can effectively cross the blood brain barrier allowing for the treatment of the central nervous system and ophthalmic symptoms, among many others. JOTROL™​ is potentially a safe and effective product for treatment in several diseases. One of the key mechanisms of action, besides modulating gene expression and activation of Sirtuins, is a boost of mitochondrial biogenesis as described below.

Mitochondrial Biogenesis

SIRT1 Activation