​JOT has developed a unique platform product, JOTROL™​, a patented reformulation of the well known "wonder" medication resveratrol. Resveratrol is poorly soluble and is rapidly metabolized by the liver which requires high doses for therapeutic effect, but is then associated with severe GI side effects. JOTROL™​ is the first and only product that delivers resveratrol in a highly bioavailabe form which can effectively cross the blood brain barrier allowing for the treatment of the central nervous system. JOTROL™​ is potentially a safe and effective product for treatment in several diseases. Key mechanisms of action, besides modulating gene expression and activation of Sirtuin's, is a boost of mitochondrial biogenesis, NrF2 and NLRP3 inflammation activation as well as an anti-inflammatory effect. 

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​Pilot study shows JOTROL™​ RSV average in plasma increased bioavailability by 22X compared to earlier human studies with over the counter (OTC) resveratrol (MCRI), Friedreich's Ataxia Study)1. and Turner et al. AD study2